Customs
Once upon a time, all you needed was an ICAO flight plan and a general declaration. Now, advance notification with crew and passenger information is standard, but as you travel across the pond and into Europe, expect varied processes. Like the US, some countries have implemented their version of eAPIS, and more are in the works.
European Differences
Flight planning and execution in Europe requires additional research and attention to detail. Knowing the differences ahead of time will give you a big leg up. Buckle up for a 30,000-ft, rapid-fire highlight-reel of differences between US and European operations.